Werewolves also known as Lykantroph (from the Greek λυκάνθρωπος: "Wolfmensch"), are according to old folklore, humans who have been cursed to transform into a wolf or human-wolf form, usually during the night of a full Moon being visible from Earth.
- In the short story "The Howl" Raphael gets involved with a werewolf.
- "Darkness Weaves" - Lilith, a singer that Shadow Jones goes to see in concert, is revealed to be a werewolf, transforming several of the concert goers into werewolves themselves by getting them to drink her blood, including Shadow's friend Sloane.
- "Raphael: Bad Moon Rising" - Raphael and Shadow find themselves dealing with the werewolves of Lilith's Sisterhood.
- On another occasion, Raphael will go into an alternative future in which the King of Thieves has gained control of the local werewolf population, and Michelangelo has been transformed into a monstrous mixture of a turtle and a werewolf.
Archie Teenage Mutant Ninja Turtles Adventures
- Dreadmon is a werewolf-like creature. He was a teenager from South Africa who grew up in Jamaica and who kept himself alive with theft, until one day he stole a magical talisman that gave him his Werewolf shape. Dreadmon is also equipped with super speed.
- Monsterex is a creature that is a hybrid of vampire, werewolf, Gill-Man, and Frankenstein's Monster.
- In the episode "Mikey Gets Shellacne", Chris Bradford (a.k.a. Dogpound) falls into a mutagen tank during a battle with Michelangelo and turns into a werewolf like creature that receives the name Rahzar from Michelangelo.
- Real Werewolves - in the form of big wolves and a anthropomorphic wolf figure feature in the episodes "The Curse of Savanti Romero," "The Crypt of Dracula," "The Frankenstein Experiment," and "Monsters Among Us!." While most of them seem more like actual wolves, the gypsy Vulko is the usual man-wolf and becomes a helper of Savanti Romero and the vampire Dracula.