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T.C.R.I, Techno Cosmic Research Institute was created by aliens known as Utroms who crash landed on planet Earth. In the 2003 cartoon, their original branch was in Japan, but one of the Guardians betrayed the Utroms to the Shredder, so they withdrew to New York in North America. While in the original Mirage Comics, they had been in New York the entire time and had nothing to do with the Shredder. During a fateful day, a company truck had lost a container of mutagen into the sewers, while at the same time, four baby turtles also went into the sewers. The building was under attack by the army and the Shredder in recent years, causing the Utroms to return back to their home world.

In the second movie it was changed to T.G.R.I: Techno Global Research Industries as the production was not supposed to have anything to do with aliens.

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