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T.C.R.I (Techno Cosmic Research Institute) is a scientific corporation/organization with a large, mysterious and imposing facility in Brooklyn, New York. Though little is known of the ongoings inside the building, their organization's acronym was printed upon the canister of mutagen which transformed the Teenage Mutant Ninja Turtles and Splinter. The facility is, in actuality, the secret terrestrial base of a race of aliens called Utroms who had crashed on the planet Earth sometime in the 1960s.
Having damaged their communication systems and lost a third of their crew in the crash, the Utroms used robotic humanoid exoskeletons and false skins to infiltrate the human population of New York City, gradually amassing enough capital to purchase a facility which they turned into their base of operations. Utilizing the slowly advancing technology of Earth, they re-established communication with the Utrom homeworld, but were then told to remain in an observational capacity.
The Utroms then spent the next decade transporting salvaged material from the spaceship crash site to the T.C.R.I. building while further developing their alien technology, including a Translocation Matrix which would eventually serve as a surreptitious portal between Earth and their homeworld. However, in 1970, a traffic incident caused a canister of chemical mutagen to fall off the truck and disappear into the sewers, never to be recovered.
Fifteen-and-a-half years later in 1985, the Teenage Mutant Ninja Turtles infiltrated the facility looking for answers about their origins and missing sensei and were discovered. In the resultant struggle between the Utroms and TMNT, the Transmat and the communications system were damaged, sending the turtles across the universe and causing a bright flash of light that was seen throughout the city. New York's authorities tried to investigate the disturbance, but upon discovering that there was no way inside, besieged the facility for three days. During that time, the Utroms retrieved the turtles, but the second flash that accompanied their return signaled the NYPD and the National Guard to begin their attack. Sending robots to hold them off, the Utroms all evacuated via the Transmat back to their homeworld and transported the turtles and Splinter to safety before triggering a self-destruct initiative which caused the building to collapse.
In the second movie it was changed to T.G.R.I: Techno Global Research Industries as the production was not supposed to have anything to do with aliens.