Snakeweed (originally just "Snake") is a villain appearing in the 2012 TV series. He worked as a driver for The Kraang, shipping their Mutagen around as well as transporting the Kraang themselves. The Turtles confront him in Rise of the Turtles, Part 1 and interrogate him. Raphael threatens him during interrogation with a vial of mutagen. After the Turtles get the information they need, they keep Snake captive, although he escapes due to Michelangelo's inattentiveness. Snake hides in an alley, where Raphael and Leonardo mock a conversation about how they will attack Kraang headquarters, knowing that Snake is listening.
Snake tells The Kraang about the Turtles' plot. Snake's van is driven into the HQ, and Snake and The Kraang attack the van, but the Turtles are not inside, as it was a distraction. The van explodes, splashing mutagen all over Snake, mutating him into a plant monster.
Snake later confronts the Turtles in his new form, with Michelangelo dubbing him "Snakeweed" and Leonardo calling him "Stinkweed". Leonardo blows him up by tricking him into the vicinity of a power core. After the Turtles leave, however, his assumed corpse is shown, and his heart begins to beat once more.