Slash appeared in two video games. The first was Teenage Mutant Ninja Turtles III: The Manhattan Project for the NES, as one of the mini bosses. He jumps off the back of Bebop's truck. Here Slash fights with a saber, and leaps around the screen, making him hard to hit. He also rolls himself into a ball and rolls up and down the screen.
He returns in Teenage Mutant Ninja Turtles IV: Turtles in Time, the SNES version of the 4-player arcade game of similar name. He is the boss of the Prehistoric stage replacing the Cement Man boss from the arcade version. Considered one of the strongest bosses of the game, he slices with his kris in combo attacks and can block the player's attacks. If Slash blocks too often, he suddenly busts out rolled in a ball, knocking the player to the floor.
Slash, in both appearances, is based more on his action figure design and original concept, rather than the cartoon version. In addition to a sword, and unlike the other turtles, he has a pair of twin metal claws attached to a band on his hand.
Slash returns, this time as an unlockable playable character in Teenage Mutant Ninja Turtles: Mutant Madness. Again, his design is based on the action figure.