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Screwloose appeared, accompanying Wingnut, in the episode Zach and the Alien Invaders. The pair attempted to take over New York City by brainwashing children into mindless puppets.

Zach's frustrated parents enroll the child in the Teen-Hut Military Academy to try and straighten him out, since he seems to see alien invaders in everything. However, shortly after enrollment, Zach discovers that his fellow cadets are zombies thanks to two aliens: Wingnut and Screwloose, who are disguised as Colonel Clout and Sergeant Rambo. Wingnut and Screwloose plan to conquer Earth using their "Mind Changer" on the young cadets.

The plot is eventually stopped by Zach, Donatello and Michelangelo when Zach uses his Turtle-Com to overload the power of the "Mind Changer." As a result, Screwloose returns to Flagenon with Wingnut.

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