Little is known about their past, other than they they were acrobats in a circus until they were both stung and mutated by Oozesquitoes (Apparently while they were both juggling crabs).
The Sando Brothers were first seen in "The Evil League of Mutants" where they attacked a biosphere and fought the Mad Dogs. They overpowered the Mad Dogs until they are teleported away. The Sando Brothers appeared in a room in the Radisson Hotel with Meat Sweats, Hypno-Potamus, Warren Stone, and Repo Mantis with Todd Capybara catering lemonade to them. Baron Draxum, Huginn, and Muninn assembled them together where they learned of his involvement in the Mad Dogs' creation as he brings them together as the Evil League of Mutants as part of a plot to defeat the Mad Dogs. During the fight against the Mad Dogs in New Jersey, the Sando Brothers and the rest of the Evil League of Mutants were defeated by the Mad Dogs who used fish and ladders fighting techniques inspired by Lou Jitsu.
Powers and abilities
Despite their mutation, the Sando Brothers have retained their skills as highly trained acrobats and aerialists, capable of outmaneuvering the Mad Dogs in battle. They also have the ability to launch their claws as projectiles and regenerate them at an extremely rapid rate.