The Rio Grande (Spanish for Great River) is a major river in North America. From its headwaters in Colorado, the river flows through New Mexico until it reaches the international border between the United States and Mexico, where it continues flowing until reaching the Gulf of Mexico in the Atlantic Ocean. On the international border, the river is bordered by the state of Texas on the U.S. side and the states of Chihuahua, Coahuila, Nuevo León and Tamaulipas on the Mexican side.

The Rio Grande features briefly in TMNT: Bebop & Rocksteady Hit the Road issue 2 of the IDW comics, as Special Agent Ravenwood of the Earth Protection Force visits the site of a massacre of United States Border Patrol agents that occurred when Bebop and Rocksteady crossed the river from the Mexican side on their way back to New York City.

MACC in the 1987 cartoon episode Attack of Big MACC also claims he is from the Rio Grande Region.

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