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Orcs are a mythological/fantasy creature. While the creature in folklore is ambiguous, translating anything from goblin to evil spirit to corpse, the orc appearing in popular culture today was devised by The Lord of the Rings author J.R.R. Tolkien as a counterpart to ogres and oni in his legendarium.
In TMNT
Back to the Sewer
Orcs are a species in SuperQuest, seemingly both playable and likely as non-playable characters.
2012 TV series
In "Turtles in Time", the knights the Turtles and Renet encounter mistake the Turtles for orcs and promise Renet that they will save her from them, despite her protests.