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New Hampshire is a state of the United States in the region of New England.
In real life, Mirage Studios was started in Dover, New Hampshire, as well as where the first Eastman and Laird's Teenage Mutant Ninja Turtles comic was published in May 1984.
In the Tales of the TMNT comic books, the short story The Trophy is set there, during the time period after the City at War arc when Splinter was still roaming the wilderness.