A Mutant plant appears in the 1987–1996 animated television series episode It Came from Beneath the Sewers.
While Shredder paid a visit to the Technodrome in Dimension X to ask Krang for help in finding the first fragment of the Eye of Sarnath that Baxter Stockman had lost, a small bit of plant-like material stuck to the side of his boot, which he inadvertently took back to Earth with him.
Following Shredder and Baxter recovering the lost fragment, an accident during Baxter's attempt to analyze it caused it to come into contact with the gunk on Shredder's boot. Upon being wiped off, the fragment's energy caused the glob to start growing into the mutant plant. Shredder realized it was the perfect weapon to deal with the Turtles while he sought out the remaining Eye of Sarnarth fragments and released it into the sewers.
After a brief attack on the Turtles in their lair, the plant eventually found its way to the surface and started to wreak havoc on the streets of New York City, forcing the Turtles to focus on it rather than the hunt for the fragments. Using the Turtle Van, they were able to fight the vines that were attacking the buildings before the plant finally showed its head, briefly clashing with the mutant heroes before retreating into the sewers. After consulting Splinter, the Turtles followed a trail of green goop the plant left behind to follow it. Upon encountering it one last time, the Turtles, using Michelangelo disguised as a female plant, were able to distract the plant long enough to launch a surprise attack on it. In the end, Leonardo destroys the plant by using one of his katana swords to cut through the planet's neck, following Splinter's advice to begin at the "root of the problem", causing it to dissolve back into the plant-like gunk it initially was.