Ms. Campbell claims to be a research scientist from the World Wide Genome Project who takes a particular interest in April O'Neil. In reality, she is a robot agent sent by the Kraang. Unlike the other Kraangdroids, she has no alien pilot and is completely mechanical. Although not as mechanical-sounding as the male drones, she tends to repeat certain phrases, as if all her speech were pre-recorded. Also unlike the other droids, she has lethal weapons built into her body and is a very powerful fighter. She was able to stand up to all four of the Turtles in combat, but they were still able to defeat her. She was destroyed in battle by having her arms and her face-plate severed, then sprayed with water, short-circuiting her.
In "TCRI", another robot identical to Ms. Campbell appears as the receptionist at the front desk of the TCRI building. Since the first Ms. Campbell was destroyed in "The Alien Agenda," this is most likely just a second robot of the same type.
She makes another appearance in "The Kraang Conspiracy", attacking the Turtles and April. Raph destroyed her by throwing one of his sais at one of her missile-launching elbows, causing her to explode.
She also makes an appearance in "Battle for New York, Part 2", where she alongside some Biotroids and Irmabots try to stop The Mighty Mutanimals from opening the portal to Dimension X to help the Turtles.