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In almost every game Mousers usually occur as normal level opponents and are often used as an annoyance enemy in TMNT games, being hard to hit and having cheap attack tactics, but have the tendency to be destroyed easily. However in some, of the video games, far greater Mousers with advanced capabilities appear:

Teenage Mutant Ninja Turtles (2003 game)

Mousers were again standard enemies, often appearing as enemies in levels that featured Dr. Baxter Stockman. The boss of Dr. Stockman's lab was a Giant Mouser Robot, which fired missiles and had arms ending in claws similar to its head. The Giant Mouser later reappeared as a mini-boss. Also featured were Prototype Mousers, which were green and slightly more powerful.

Teenage Mutant Ninja Turtles 2: Battle Nexus

Mousers reappear in the first two stages of the game, along with the first tournament of tournament mode. Other modified, stronger versions of the Mouser appear in a number of later stages.

TMNT: Mutant Melee

Mousers appear in clear boxes in the "Lab" stage; they serve no direct purpose, other than acting identical to the crates available in the game's other stages. Certain levels have Mousers that can spring forth from the ground and act as a distracting nuisance. Another stage features a Giant Mouser chasing the players through the sewers. Also Mousers are playable when you're character dies in Melee Mode you take control of a Mouser but they can't do any damage they're just used to distract opponents by biting them

Teenage Mutant Ninja Turtles 3: Mutant Nightmare

There's a legion of Mousers that seem to only be under the employ of Agent Bishop. With elongated heads and electrically charged bodies, these Mousers were slightly stronger than the standard ones, but not as powerful as Dr. Chaplin's Mouser v2.0 series. These Mousers came in red and green hues. Standard Mousers and Mouser 2.0 variations also appeared in this game, coming in standard and purple variants.

Teenage Mutant Ninja Turtles: Battle for the City

Mousers are the enemies of the first level and two Giant Mousers are the boss.

Teenage Mutant Ninja Turtles: The Way of the Warrior

Mousers appear in the "Mouser Attack" mode of the game.

Teenage Mutant Ninja Turtles: Double Damage

They are enemies in the game.

Teenage Mutant Ninja Turtles: Arcade Attack

They are enemies in the game.

Mouser Variations

There are also various other models of Mousers, but these are mostly prototypes or test models.

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