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Mother Mousers are a sub-boss appearing in the video game Teenage Mutant Ninja Turtles III: The Manhattan Project. They are quite a bit larger than a standard Mouser, but are much smaller than their predecessor and successor. Mother Mousers are not completely autonomous, and require a Foot Soldier to pilot them. Mother Mousers attack with leaping bites, plasma bolts, and their regular-sized Mouser brood.

In Teenage Mutant Ninja Turtles: Shredder's Revenge, the heroes come across some Mother Mousers beginning in Stage 5. These Mousers act as sort of a mini-boss in that they take much more effort to defeat than standard enemies, albeit that players will often fight two or three at once.

These Mouther Mousers are similar in a couple of ways to Teenage Mutant Ninja Turtles III: The Manhattan Project's Mother Mousers, in that they spawn smaller Mousers to attack with (although these ones spit them up), and can capture the player's head in its mouth with a fierce bite. However, they lack the Foot Soldier rider and mouth laser of their predecessors.

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