Mind Control Serum was created by Baxter Stockman with the help of Hun's power over the Auman Chemicals factory. Shredder ordered the serum so he could get his "daughter" back.
- Casey Jones VS. The Underworld - Donatello finds out the chemicals that were being prepared by the Foot Clan were meant to create a Mind Control Serum.
- The Noxious Avenger - Bebop and Rocksteady stole a chemical called Reagent-X for the serum and Rocksteady reveals the serum is to be used on Karai.
- Clash of the Mutanimals - Baxter Stockman uses mutagen and the serum to create mind controlling worms.