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The Mighty Mutanimals are a squad of mutants who are a friendly party to the Ninja Turtles and actively engage in heroics. The Mutanimals are usually brought in as "backup" for the Turtles in missions too dangerous for the four of them (plus ordinarily, Casey and April) to tackle on their own.

Some of the roster appeared individually in previous games, but their first appearance as a team was in the mobile gacha/idle RPG Teenage Mutant Ninja Turtles Legends. Players could receive increased chances of snagging any of the characters in special Mutanimals events or missions, and they worked as a team together in story scenes.

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