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Madison Square Garden is a significant location in the IDW continuity's Teenage Mutant Ninja Turtles/Ghostbusters. In the Ghostbusters' dimension version of New York City, the deity Chi-You seizes control of several players in the middle of a professional ice hockey game and transforms them into his thralls.
The New York Knicks basketball team plays its home games inside the Madison Square Garden, as seen in the beginning of the film Out of the Shadows. The Turtles watch a New York Knicks home game inside the Madison Square Garden from a rafter, when Michelangelo accidentally drops a slice of pizza onto the court.