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A homunculus (plural homunculi) is an artificial human, usually created via alchemy, magic, or science. Historical homunculi were incredibly small (homunculus is Latin for "tiny man"). Although they were once accepted as a factual creation, it known today to be mere folklore.
In Volume 4, April O'Neil discovers that she was never naturally born, but was drawn to life by her father using the Warp Crystal, which Kirby would rediscover in the Second Time Around's basement in Kirby and the Warp Crystal. It explained why April was not genetically related to either of her parents or her sister, and why she was unable to become pregnant by her husband Casey Jones or any man. April's continued existence was linked to an drawing John made of her as the previously fictional baby girl she became in real life, and was disturbed by the knowledge that not only do these created beings tend to vanish after a while as the drawings and paper degrade, but that she was just the last in a series of previous infants who had been drawn to life, but all the ones who came before her had only lived a short time before vanishing; for April's drawing, John reinforced the drawing with ink and kept it protected so that April could live longer, but there was never a guarantee how well the drawing would age before April, too, would disappear. April subsequently had a major existential crisis, feeling so much like she was actually nobody that, for a time, she took up the moniker of their fallen friend Nobody and threw herself into vigilante fighting. When Casey found "Nobody" and realized it was April, she told him of her discovery. After this, April said goodbye to her husband and stepdaughter Shadow and left on a cross-country road trip to figure herself out, not admitting to them that she actually expected to die far from home. In the story White Horses, April travels to Kruzof Island in Alaska's Alexander Archipelago, befriending a Tlingit woman named Onida. April admitted things to Onida that she had not even told her family or friends, and Onida told her that living and dying are choices. After a near-death experience on one of the island's cliffs, April makes a determined decision to live, no matter what she is or where she came from. Later in Volume 4, April was last seen driving her motorcycle back towards her home in New York City.