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Harlem is a real life neighborhood in New York City's borough of Manhattan. Originally a Dutch colonial village, since the 1920s it has been associated with a large African-American population and, in its eastern portion, a large Hispanic-American population.

The Harlem neighborhood is the central setting of Disposable Heroes, as David Merryweather resides there.

In the Mirage continuity, King Cobra also runs a club, The Snake Pit, there.

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