The episode begins in the night sky where a raptor eyes a fish, which has just eaten a worm, swimming in a stream down below and grabs it in its talons before flying off with its catch. The scene then switch to the events from the previous episode, where Donnie and Casey are fighting the Speed Demon and are about to be defeated by it when the arrival of the others in the Party Wagon saves the day, as they slam into the mutant car, sending it flying over the nearby cliff. Unfortunately for the bird, it happens to fly right by the Speed Demon as it plummets over the cliff, resulting in the bird being doused in Mutagen from head to toe, along with the fish in its talons, in addition to the worm recently consumed by the fish, causing the three to amalgamate. Now as a repulsive mutant, the former raptor flies off into the night.
At the farm, April has donned a device on her head a psychic neuro-transmitter which Donnie created (from technology he salvaged from the Kraang Scout Ship) and intends to find out more about April's psychic powers by giving her a test (while she's wearing it) that requires her to rely on her intuition to determine what figure is pictured on the side of a card facing away from her. Mikey enters the barn to oversee the results. April expends a lot of mental effort, but fails to identify the object on the opposite side of every card. However, her failures are quick to be redeemed after Donnie increases the frequency of the neuro-transmitter significantly, whereby April has an immediate reaction of telekinetically levitating the cards in the barn, astounding Donnie and Mikey alike. Donnie then speaks to April, but a delay in her verbal response puzzles Donnie. April soon stands up from her chair, but stumbles around the barn, claiming that she can't see her surroundings. April then remarks that she's seeing clouds, further garnering the puzzlement of the two turtle brothers in her presence.
Outside the farmhouse, Leonardo, Raphael, and Casey are preparing to train, Leonardo ambitiously remarking on the fact that he's feeling a lot better than usual and is ready to take both Raph and Casey down. Unfortunately, Leo proves himself wrong while parrying the attacks of his teammates, as he falls to his right knee, once again injuring himself. Raph and Casey make haste to help him up and walk him back to the porch of the farmhouse. Leo and Raph attempt to cheer up a disconcerted Leo, but he botches their attempt, negatively remarking that he can't spar with them, he can only watch, and that that's all he's good for anymore.
Inside the barn, April's obscure vision of the clouds slopes downward and heads directly toward Raph and Casey, which she tells to Donnie and Mikey and the two brothers (sans April) make haste to prevent Raph and Casey from being harmed by the apparent thing that April is seeing through the eyes of. As Donnie and Mikey head outside, they discover a behemoth mutant assailing Raph and Casey, true to what April informed them of. Donnie, Raph, Mikey and Casey fight valiantly against the repulsive Chimera, but the beast is far too large for them to catastrophically injure and they are captured by it and taken to the top of a nearby rocky peak, according to what April can see (and feel) through her psychic connection with the Chimera (acquired when Donnie increased the frequency to the neuro-transmitter).
On the rocky peak, the creature drops its four victims in its nest, which is filled with numerous human skeletons. They seek to escape the nest and rush into a crack of the mountain. Donatello and Michelangelo fail to fall into a boiling water under pressure, a kind of geyser that seems about to wake up. None of them took his spear grapple alone Raphael rope. Meanwhile Leonardo and April are trying to figure out how to climb the peak, with the turtle's injury. April suddenly starts behaving like a hen, and wants to eat Leo. Even before leaving the farm, she felt like she was starving, much like that of Mikey. Leo dodges, and without realizing it at first, notices his knee has recovered. Now they can go to the rescue of their friends.
Raphael launches Mikey's kusarigama, attached to his rope. But when they climb the wall, the chimera raised its long neck into the hole and cut its beak rope. This time, more rope to climb, and time is short. Leonardo and April reached the top of the peak shortly after and found the hole where the others are retained turtles and Casey. They do not have the time to help them as the chimera comes back and catch his talons. But Leo does not stay very long retained, he defeated the clutches of the animal, and goes on his neck, releasing the same time April. Chimera changes course, moving from above the clouds in a lake and then returns to the forest canopy before crashing into the hole through which fell turtles and Casey. The monster is offside, but the hole is plugged, the pressure may rise along water geyser; so you have even more to hurry. Leonardo clears the hole by pushing the creature and other climbing by its long neck. There is no time to lose, they evacuate the rocky peak, which explodes. The explosion cause some rocks to break loose a cause an avalanche. The gang takes cover during the rock slide. April suddenly begins sees again with her own eyes, since the physical link between her and the Chimera is now broken.
Back at the farm, Donatello apologizes for having tested the machine on April. But since it no longer sees that saw what the mutant saw, she especially regrets what happened to him, the Chimera is certainly dead. In fact, a little squirrel who was passing by eating a nut gets caught by the Chimera, recovering from under the fallen stones.
The Chimera was, according to Greek mythology, a monstrous fire-breathing hybrid creature, composed of the parts of more than one animal. Usually depicted as a lion, with the head of a goat arising from his back, and a tail that might end with a snake's head. Due to its combination of animal features, the term is often used in modern parlance to refer to any hybrid.
"Eyes of the Chimera" is another name of Heterochromia Iridium, a genetic anomaly in which each eye of the individual has a different coloration.
In a tie-in to Michelangelo describing the "Turducken" as a mythological hybrid when Donatello correctly guessed that the creature was a Chimera, Turducken is a dish consisting of a deboned chicken stuffed into a deboned duck, which is in turn stuffed into a deboned turkey. The word turducken is a portmanteau of turkey, duck, and chicken. The dish is a form of engastration, which is a recipe method in which one animal is stuffed inside the gastric passage of another.
This episode featured an active geyser in North Hampton which is located on Talbot Peak. In real life, there are no geysers in the state of New York, or anywhere in the northeastern United States.