Mrs. Cuddles is a stuffed rabbit toy with a dark blue body, a light blue muzzle and belly and a white cotton-ball tail. She also has long, rainbow-colored floppy ears, buck teeth, large eyes with black pupils (which sometimes glow red), thick eyelashes, and a red nose. Mrs. Cuddles also wears a yellow bow on top of her head.
Originally, Mrs. Cuddles was a simple puppet who acted as the protagonist on a children's television show, but somehow acquired a life of her own and sentience, as well as the ability to absorb the fear that those around her manifested, in the form of screams that caused her to gain size and strength.
Mrs. Cuddles was brought to the Turtles' lair by April O'Neil, who had been cast in her show, in order to prank their would-be leader Raphael. Raphael for no known reason, was very afraid of plush dolls. Because of his phobia, he was the prey she needed to gather enough strength to frighten the rest of the Turtles and April, triggering more fearful screams. In her final confrontation with Raphael and Splinter, the mutant rat began laughing loudly, which drained Mrs. Cuddles' power. Reduced to the size of an ordinary doll again, she was locked in her case by Raphael.
Mrs. Cuddles' power is sourced from fearful screams. The more someone screams, the bigger she becomes. However, when someone laughs, Mrs. Cuddles shrinks.
- "Now give me a scream!"
- "No Raphie! Just widdle ol' me!"
- "Who wants a pickle-wickle?!"