The Bronx is the northernmost of New York City's five boroughs, and the only one located chiefly on continental North America and not on an island. It is bordered to the north by Westchester County, New York, to the northwest by the Hudson River (across from which is New Jersey), to the west by the Harlem River (across from which is the island of Manhattan), to the south by the East River (across from which is the borough of Queens), and to the east by Long Island Sound. A small strip of land surrounded by the northwest Bronx and the Harlem River is actually part of the borough of Manhattan, though not located on the island of Manhattan.

In the original 1989 video game, the game's fifth area takes place on a base of the Foot Clan operating out of the South Bronx.

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