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The laboratory of Baron Draxum is a recurring location in Rise of the Teenage Mutant Ninja Turtles. Located in the Hidden City, the laboratory is where Draxum conducted his alchemy research, including mutagen and oozesquitoes. It was also Draxum's home as well as home to his servants Huginn and Muninn.

Since Season 2, Draxum became a wanted fugitive in the Hidden City and could no longer live or work in his lab. Forced into a new life above ground among humans, he moved into an apartment and found a new job as a cook in the cafeteria of April O'Neil's high school. Draxum's lab would however reappear in "Anatawa Hitorijanai", where Draxum attempted to confront the Shredder only to be defeated. During this fight, the laboratory would be trashed by the Shredder.

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