He appears in Teenage Mutant Ninja Turtles (Game Boy Advance) during Raphael's chapter which adapts "Meet Casey Jones". Raphael must beat Casey in a motorcycle race with the Shell Cycle, and then Casey becomes an assist character for the last part of the chapter.
Casey Jones is also present in the console version of the first game as a boss that can only be encountered when playing as Raphael. Defeating Casey Jones unlocks him as a playable character.
Casey Jones appeared once more as an unlockable playable character in the console version of Teenage Mutant Ninja Turtles 2: Battle Nexus.
He also appears in the game Teenage Mutant Ninja Turtles 3: Mutant Nightmare.