
The American Museum of Natural History is a real museum in New York City.
Although it is not specified, it is very possible that this is the museum that April, Don and Mike visit in "The Return of Savanti Romero!" within the original Mirage continuity.
The Turtles and April visit this museum in the episode "Return of Savanti, Part 1" for the 2003 TV series.
In the film Out of the Shadows, fictional scenes take place there.[1] At the museum, Shredder, Bebop and Rocksteady find the second component from the Krang machine sent by him to Earth a long time ago.[2] Leonardo and Donatello show up shortly thereafter, and Donatello discerns what it was that Shredder retrieved there.