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Ōsaka (Japanese kanji: 大阪; hiragana: おおさか, lit. "large hill" or "large slope") is a city on the island of Honshū in Japan. According to Teenage Mutant Ninja Turtles Adventures issue #45: Mutations, Hamato Yoshi studied at Ōsaka University.[1]
The original action figures of Shredder and Splinter also list Ōsaka as their birthplace.